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. 2016 Mar 11;310(10):H1321–H1329. doi: 10.1152/ajpheart.00890.2015

Fig. 5.

Fig. 5.

EETs-mediated dilation is impaired in PAs from BCAS rats. A: PAs from Sham rats were incubated with l-NAME and Indo before the generation of tone. Dilation to carbachol remained unaltered in the presence of the inhibitors in PAs from Sham rats. B: inhibition of production of NO and prostacyclin had no effect on dilation in PAs from BCAS rats. C: inhibition of EETs production with MS-PPOH abolished dilation in PAs from Sham rats. D: incubating with MS-PPOH had no effect on dilation in PAs from BCAS rats. E: dilation to TRPV4 agonist GSK 1016790A was reduced in PAs from BCAS rats. F: no difference in myogenic tone generation with addition of the inhibitors; n = 4–6. *P < 0.05, different from Sham rats.