Table 1.
Animal characteristics
| Variable | WT-SED | WT-EX | FGF21KO-SED | FGF21KO-EX |
|---|---|---|---|---|
| Body weight, g | 29.3 ± 1.2 | 26.9 ± 0.5†‡ | 37.4 ± 0.8*‡ | 31.6 ± 0.8†* |
| Running distance, km/day | NA | 7.75 ± 0.60 | NA | 6.96 ± 0.73 |
| Heart weight/liver weight, mg/g | 5.24 ± 0.16 | 5.83 ± 0.19† | 4.58 ± 0.14* | 5.74 ± 0.23†* |
| Liver weight, mg | 1,251.5 ± 56.5 | 1,262.6 ± 28.6 | 1,693.2 ± 69.3* | 1,565.1 ± 38.7* |
| Liver weight/body weight, mg/g | 42.68 ± 0.76 | 47.04 ± 1.02† | 45.29 ± 1.49* | 49.77 ± 1.16†* |
| Fat mass, g | 5.3 ± 0.9 | 2.7 ± 0.4†‡ | 10.8 ± 0.4*‡ | 5.6 ± 0.6†* |
| Lean mass, g | 22.9 ± 0.6 | 22.9 ± 0.3 | 25.9 ± 0.4* | 25.1 ± 0.4* |
| Percent body fat, % | 17 ± 2 | 10 ± 1† | 29 ± 1* | 17 ± 1†* |
| Percent lean mass, % | 79 ± 2 | 86 ± 1† | 69 ± 1* | 80 ± 1†* |
| Food consumption, g/wk | 25.8 ± 0.2 | 32.3 ± 0.7† | 28.6 ± 0.2* | 33.7 ± 0.8†* |
| Feeding efficiency | 0.024 ± 0.004 | 0.006 ± 0.002† | 0.033 ± 0.003 | 0.009 ± 0.003† |
Values are means ± SE (n = 9–15).
*
Significant genotype main effect (P ≤ 0.05);
†
significant exercise main effect (P ≤ 0.05);
‡
significantly different than WT-SED and FGF21KO-EX (P ≤ 0.05).
NA, not applicable. WT, wild-type; FGF21-KO, FGF21 knockout; SED, sedentary; EX, exercise.