Table 3.
The association of BMI with any subsequent psychotropic medication as well as antidepressant and sedative medication: Cox regression analysis (hazard ratios, HR, and their 95 % confidence intervals (95 % CI)
| Model 1 | Model 2 | Model 3 | Model 4 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| BMI (kg/m2)a | HR | 95 % CI | HR | 95 % CI | HR | 95 % CI | HR | 95 % CI | |
| Any psychotropic medication | |||||||||
| Women | Normal weight | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Overweight | 1.06 | 0.95–1.19 | 1.00 | 0.89–1.12 | 0.97 | 0.87–1.09 | 0.94 | 0.84–1.06 | |
| Obese | 1.05 | 0.89–1.24 | 0.93 | 0.78–1.10 | 0.90 | 0.76–1.06 | 0.84 | 0.71–1.00 | |
| Severely obese | 1.23 | 0.94–1.61 | 1.23 | 0.94–1.61 | 1.16 | 0.89–1.53 | 1.03 | 0.79–1.36 | |
| Men | Normal weight | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Overweight | 1.18 | 0.91–1.51 | 1.14 | 0.88–1.47 | 1.12 | 0.87–1.44 | 1.09 | 0.84–1.41 | |
| Obese | 1.57 | 1.10–2.24 | 1.37 | 0.96–1.97 | 1.26 | 0.87–1.82 | 1.15 | 0.79–1.66 | |
| Severely obese | 2.15 | 1.29–3.56 | 1.76 | 1.06–2.92 | 1.51 | 0.90–2.53 | 1.19 | 0.70–2.03 | |
| Antidepressants | |||||||||
| Women | Normal weight | 1.00 | - | 1.00 | - | 1.00 | 1.00 | - | |
| Overweight | 1.10 | 0.96–1.26 | 1.05 | 0.91–1.20 | 1.00 | 0.86–1.15 | 0.96 | 0.83–1.11 | |
| Obese | 1.20 | 0.99–1.46 | 1.08 | 0.89–1.32 | 1.02 | 0.83–1.25 | 0.94 | 0.77–1.16 | |
| Severely obese | 1.32 | 0.95–1.82 | 1.29 | 0.93–1.77 | 1.15 | 0.83–1.60 | 1.01 | 0.72–1.40 | |
| Men | Normal weight | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Overweight | 1.17 | 0.87–1.58 | 1.12 | 0.83–1.52 | 1.10 | 0.81–1.49 | 1.09 | 0.80–1.48 | |
| Obese | 1.44 | 0.93–2.22 | 1.20 | 0.77–1.86 | 1.05 | 0.67–1.65 | 0.95 | 0.60–1.50 | |
| Severely obese | 1.78 | 0.94–3.37 | 1.36 | 0.72–2.59 | 1.10 | 0.57–2.11 | 0.93 | 0.48–1.80 | |
| Sedatives | |||||||||
| Women | Normal weight | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Overweight | 1.01 | 0.88–1.17 | 0.95 | 0.82–1.09 | 0.92 | 0.80–1.07 | 0.92 | 0.79–1.06 | |
| Obese | 0.91 | 0.73–1.13 | 0.79 | 0.64–0.99 | 0.78 | 0.62–0.98 | 0.76 | 0.61–0.95 | |
| Severely obese | 1.07 | 0.75–1.53 | 1.06 | 0.74–1.50 | 1.04 | 0.73–1.49 | 0.99 | 0.69–1.43 | |
| Men | Normal weight | 1.00 | - | 1.00 | - | 1.00 | - | 1.00 | - |
| Overweight | 1.26 | 0.91–1.73 | 1.26 | 0.91–1.73 | 1.27 | 0.92–1.75 | 1.21 | 0.87–1.68 | |
| Obese | 1.69 | 1.09–2.63 | 1.50 | 0.96–2.34 | 1.44 | 0.91–2.27 | 1.38 | 0.88–2.19 | |
| Severely obese | 3.09 | 1.77–5.39 | 2.61 | 1.49–4.55 | 2.44 | 1.38–4.31 | 2.12 | 1.17–3.84 | |
a Body mass index (BMI) was categorised into four groups: normal weight 18.5–24.9 kg/m2, overweight 25–29.9 kg/m2, obese 30–34.9 kg/m2 and severely obese ≥35 kg/m2
Model 1: Adjusted for age
Model 2: Adjusted for age and previous psychotropic medication
Model 3: Adjusted for covariates in model 2, socio-demographic factors, health behaviours and strenuousness of work
Model 4: Adjusted for covariates in model 3, physical functioning and somatic health