Table 2.

Caffeine citrate dosing regimens and caffeine serum concentrations during TDM

Dosing regimens	Number of patients	Caffeine serum concentration (mg/L)
40/5 mg/kg
q12h	47	23 (18–26)***
20/5 mg/kg
q24h	49	15 (11–17)
q12h	8	17 (13–20)
5/5 mg/kg
q24h	6	13 (8–17)
q12h	5	22 (21–23)

Data = median (interquartile range)

^*** p < 0.001, significant differences were observed in caffeine serum concentrations between regimen 40/5 mg/kg q12h and standard 20/5 mg/kg q24h