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. 2016 Jun 6;213(5):535–542. doi: 10.1083/jcb.201511053

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© 2016 Hu and Butte

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Figure 5. — Cyclical force in LatA-treated cells does not increase the number of engagements. Amplitude of force oscillations over time during application of cyclical forces for LatA-treated cells with anti-CD3–treated (A) and control-treated (B) cells with pMHC-coated tips. For clarity, every fourth cycle is plotted, showing amplitude from maxima to minima. (C) Comparison of force amplitudes for the first cycle (1) and the final cycle (80), showing that treatment with LatA blocks an increase in force oscillations over the experiment. Data were pooled for cyclic contacts with pMHC without LatA (n = 5 cells from two independent experiments), cyclic contacts with anti-CD3 with LatA (same cells as Fig. 4), cyclic contacts with anti-CD43 (n = 5 cells), and cyclic contacts with anti-hCD25 (same cells as Fig. 4). ns, not significant.