Table 3.

Voxel level statistical comparing RSI-MRI cellularity index between prostate cancer Gleason categories versus normal tissues and between pathological grades. Post-hoc multiple comparison t-tests were implemented in comparing difference in detection of PCa aggressiveness (low grade PCa (primary Gleason 3) and high grade PCa (primary Gleason ≥4)) vs. benign tissue and between tumor grades (low grade PCa vs. high grade PCa).

Group		Mean difference (standard error)	p-value
Pathology vs. normal
	Low grade vs. normal	1.153 (0.100)	< 0.001
	High grade vs. normal	1.516 (0.063)	< 0.001
Between Pathological grades
	High grade vs. Low Grade	0.364 (0.113)	= 0.003

Abbreviations: PCa, prostate cancer