Potential mechanisms mediating the beneficial effect of wheel running on LPS-induced inflammation. TLR4 protein content in liver (A), MyD88 protein content in liver (B), FST mRNA expression in liver (C), circulating FST in serum (D), HSP70/72 protein content in liver (E), and PCSK9 protein content in liver (F). Two-way ANOVA P values indicated in text and when a significant interaction occurred, †P < 0.05 indicates LPS different within SED or VWR group and ‡P < 0.05 indicates VWR different within LPS group. Inset: displays fold change compared with SAL control and *P < 0.05 for t-test between groups.