. Author manuscript; available in PMC: 2016 Jun 7.

Published in final edited form as: Pharmacogenomics. 2015 Jul 31;16(12):1329–1342. doi: 10.2217/pgs.15.86

Table 3.

Information of associated SNPs.

Gene	SNP	Chromosome	Position GRCh38	Location	Alleles	MAF^†
Gene	SNP	Chromosome	Position GRCh38	Location	Alleles	EA	AA
Serotonergic

HTR1B	rs6296	6	77462543	Val287=	G/C	0.24	0.26

HTR2A	rs1923882	13	46837526	Intron	G/A	0.24	0.38
	rs9567735		46845069	Intron	A/G	0.13	0.09
	rs6561333		46846177	Intron	G/A	0.40	0.17

HTR2B	rs6437000	2	231112813	Intron^‡	A/C	0.34^§	0.19
HTR2B	rs17586428		231124141	Intron^‡	A/G	0.07	0.38

HTR3A	rs1150226	11	113974819	Upstream	C/T	0.07	0.34
	rs897687		113985089	Intron	A/G	0.01	0.41
	rs1176713		113989703	Leu497=	A/G	0.23	0.24

HTR3B	rs3758987	11	113904553	−381	A/G	0.24	0.41
	rs11606194		113910259	Intron	T/C	0.04^¶	0.01
	rs1176744		113932306	Tyr129Ser	A/C	0.29	0.39

S100A10	rs3791153	1	151985668	Intron	T/C	0.39	0.35
S100A10	rs12083193		151990213	Intron	G/C	0.39	0.35

SLC18A2	rs363271	10	117267900	Intron	T/G	0.13	0.35
	rs2244249		117272764	Intron	G/A	0.16	0.34
	rs363276		117274298	Intron	C/T	0.17	0.38

SLC6A4	rs2020942	17	30219896	Intron	A/G	0.34	0.24
	rs2066713		30224647	Intron	C/T	0.34	0.24
	rs16965628		30228407	Intron	G/C	0.08	0.27
	rs2020933		30234737	Intron	T/A	0.07	0.29

TPH1	rs10741734	11	18023101	Intron	A/G	0.45	0.20
	rs1799913		18025708	Intron	C/A	0.45	0.20
	rs1607395		18028189	Intron	T/C	0.45	0.20

TPH2	rs6582078		71981111	Intron	T/G	0.41	0.41
	rs1487275		72016512	Intron	T/G	0.32	0.29
	rs2220159		72112507	Downstream	A/C	0.22	0.34

Adrenergic

ADRA1A	rs2291776	8	26754119	Intron/3′UTR^#	G/A	0.05	0.18
	rs11135955		26781393	Intron	T/G	0.12	0.15
	rs6990485		26826850	Intron	G/C	0.00	0.24
	rs472151		26834850	Intron	G/A	0.47^§	0.29
	rs10503800		26838100	Intron	G/A	0.36	0.46
	rs486179		26866417	Intron	G/A	0.04	0.27
	rs2644627		26869124	5′ UTR/upstream^#	C/G	0.44	0.36

ADRA2B	rs2312955	2	96111420	Downstream	G/T	0.27	0.18

SLC6A2	rs36024	16	55672479	Intron	C/T	0.45^§	0.45
	rs10521329		55686546	Intron	C/A	0.17	0.33
	rs3785155		55688478	Intron	G/A	0.13	0.24

Genes are listed in alphabetical order for each pathway. Alleles are listed with the major allele first.

^†

In controls.

^‡

This SNP is also located at the overlapping PSMD1.

^§

The minor allele in African–Americans is the major allele in European ancestry.

^¶

This SNP was not excluded based on MAF of 0.08 in cases.

The position depends on the isoform.

AA: African–American; EA/ME: European/Middle Eastern; MAF: Minor allele frequency.