. Author manuscript; available in PMC: 2016 Jun 7.

Published in final edited form as: Pharmacogenomics. 2015 Jul 31;16(12):1329–1342. doi: 10.2217/pgs.15.86

Table 5.

HTR3A 3-SNP genotype.

Genotype group	rs1150226 Upstream	rs897687 Intron	rs1176713 Leu497=	AA					EA
				Controls		OD + CD			Controls		OD
				N	F	N	F		N	F	N	F
Reference	CC	AA	AA	21	0.10	80	0.14		115	0.50	380	0.46
Risk^†	CC	AA	AG/GG	36	0.17	145	0.25	↑	84	0.36	322	0.39
Protection^‡	CT	AG	AA	101	0.49	223	0.38	↓	26	0.11	97	0.12
Mixed^§	CT	AG	AG	49	0.24	143	0.24		6	0.03	28	0.03
Incomplete				0		3			1		1
Total				207		594			232		829

AA: χ² = 9.48, df = 3, p = 0.024; EA: χ² = 1.26, df = 3, p = 0.74.

^†

This group includes two 3-SNP genotypes in which there is at least one of the minor G allele for SNP rs1176713.

^‡

This group includes two major 3-SNP genotypes and six rare genotypes in which there is at least one T allele for SNPs rs1150226 or one G allele for rs897687.

^§

This group includes one major 3-SNP genotype and ten rare genotypes in which there is at least one of the minor allele for either of the three SNPs.

AA: African–American; EA: European ancestry; F: Frequency; N: Number.