Skip to main content
. 2016 Mar 11;310(10):L928–L939. doi: 10.1152/ajplung.00395.2015

Fig. 6.

Fig. 6.

Chronic treatment with ivacaftor and C18 decreases effective viscosity of the mucus layer of homozygous F508del monolayers. A: representative particle tracings of F508del/F508del HBE monolayers treated with vehicle (black) and C18 + VX-770 (gray). B: movement of each particle was quantified to give MSD of cells treated with vehicle, C18, VX-770, or the combination. C: viscoelastic curves of particles applied to the mucus layer of monolayers. D: effective viscosity of the mucus layers at 0.9 Hz. G551D/F508del HBE cells treated with VX-770 demonstrate similar CFTR activity with or without bicarbonate transport measured by the change in Isc in response to forskolin (E) or CFTRInh-172 (F). n = 4–6. *P < 0.05.