P-values of the association tests for the DMN and SNPs for genes AMOTL1 and APOE. (A,a and B,a) Univariate test for single-SNP–single-trait association; (A,b and B,b) aSPU test for single-SNP–multitrait association; (A,c and B,c) aSPUset test for gene–multitrait association.