Table 3. P-values of the gene-based association tests with the ADNI-GO/2 and ADNI-1/GO/2 data.
| Data | Gene region | No. SNPs | Chr | GEE | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Position | Score | aSPUset | aSPUset-Score | MANOVA | MDMR | MFLM | |||||
| ADNI-GO/2 | AMOTL1 | 13 | 11 | 94,481,507 | 94,629,918 | 0.723 | 0.896 | 0.940 | 0.698 | 0.716 | 0.638 |
| APOE | 13 | 19 | 45,389,277 | 45,432,652 | 0.083 | 0.042 | 0.056 | 0.097 | 0.366 | 0.974 | |
| ADNI-GO/2 with identical SNP sets of ADNI-1 | AMOTL1 | 6 | 11 | — | 0.639 | 0.552 | 0.576 | 0.638 | 0.918 | 0.638 | |
| APOE | 6 | 19 | — | 0.308 | 0.019 | 0.024 | 0.292 | 0.065 | 0.292 | ||
| ADNI-1/GO/2 with identical SNP sets of ADNI-1 | AMOTL1 | 6 | 11 | — | 1.0e-08 | 1.0e-08 | 1.0e-08 | 1.0e-08 | 1.0e-08 | 1.0e-08 | |
| APOE | 6 | 19 | — | 1.0e-08 | 1.0e-08 | 4.45e-06 | 1.0e-08 | 1.0e-08 | 4.45e-06 | ||