Table 1. Frequency of heart defects on mutant and trisomic genetic backgrounds.
| Phenotype | Genetic background | % of affected | Total no. | Type of septal defect |
|---|---|---|---|---|
| Creld1+/− | B6J/C3Ha | 0 | 18 | Not applicable |
| B6J | 0 | 27 | ||
| Ts1Cje | B6J/C3Hb | 17.2 | 29 | 4 membranous VSDs,c 1 secundum ASDd |
| Ts1Cje;Creld1+/− | B6J/C3Hb | 13 | 31 | 3 membranous VSDs, 1 secundum ASD |
| Ts1Rhr | B6J | 11.1 | 18 | 2 muscular VSDs |
| Ts1Rhr;Creld1+/− | B6J | 8 | 25 | 1 membranous VSD, 1 secundum ASD |
a
50% B6, 50% C3H.
b
75% B6, 25% C3H.
c
VSD, ventricular septal defect.
d
ASD, atrial septal defect.