Table 3.
Forty-two differentially modulated miRNA's in established tolerance (TOL as compared to normal livers. Data expressed as mean and standard error of the mean (SEM).
| miRNA | Established Tolerance (mean±SEM) | Normal liver (mean±SEM) | Adjusted P-value | Direction in TLID100 vs. NORM |
|---|---|---|---|---|
| mmu-miR-542-5p | 1.2 ± 0.0 | 0.1 ± 0.0 | 2.8×10−5 | Up |
| mmu-miR-872 | 1.1 ± 0.0 | 42.3 ± 3.1 | 1.8×10−4 | Down |
| mmu-miR-484 | 2.0 ± 0.2 | 0.1 ± 0.0 | 3.0×10−4 | Up |
| rno-miR-190b | 1.5 ± 0.2 | 4897.7 ± 493.0 | 5.8×10−4 | Down |
| mmu-miR-138 | 0.7 ± 0.0 | 1.6 ± 0.1 | 0.0012 | Down |
| rno-miR-466c | 2.9 ± 0.3 | 0.6 ± 0.2 | 0.0022 | Up |
| rno-miR-381 | 5.8 ± 0.7 | 1.2 ± 0.1 | 0.0029 | Up |
| mmu-miR-18a | 1.4 ± 0.2 | 0.2 ± 0.1 | 0.0030 | Up |
| mmu-miR-194 | 0.5 ± 0.1 | 1.5 ± 0.1 | 0.0034 | Down |
| mmu-miR-107 | 0.7 ± 0.3 | 15.4 ± 2.4 | 0.0036 | Down |
| mmu-miR-342-3p | 3.7 ± 0.6 | 0.3 ± 0.1 | 0.0041 | Up |
| mmu-miR-142-3p | 2.9 ± 0.2 | 1.2 ± 0.3 | 0.0047 | Up |
| mmu-miR-142-5p | 3.5 ± 0.4 | 0.9 ± 0.2 | 0.0057 | Up |
| mmu-miR-365 | 0.1 ± 0.0 | 1.4 ± 0.2 | 0.0057 | Down |
| mmu-miR-27b | 0.5 ± 0.0 | 1.2 ± 0.1 | 0.0063 | Down |
| mmu-miR-20a | 0.9 ± 0.1 | 1.7 ± 0.1 | 0.0071 | Down |
| mmu-miR-320 | 0.7 ± 0.1 | 1.8 ± 0.2 | 0.0076 | Down |
| mmu-miR-671-3p | 1.1 ± 0.0 | 1.4 ± 0.1 | 0.0080 | Down |
| mmu-miR-151-3p | 0.4 ± 0.1 | 3.0 ± 0.5 | 0.0092 | Down |
| mmu-miR-7a | 0.8 ± 0.1 | 0.2 ± 0.0 | 0.0101 | Up |
| mmu-miR-361 | 0.7 ± 0.1 | 1.2 ± 0.1 | 0.0110 | Down |
| mmu-miR-125a-5p | 5.1 ± 0.5 | 2.3 ± 0.4 | 0.0111 | Up |
| mmu-miR-672 | 0.4 ± 0.1 | 1.6 ± 0.2 | 0.0114 | Down |
| rno-miR-333 | 1.0 ± 0.3 | 4.7 ± 0.8 | 0.0115 | Down |
| mmu-miR-125a-3p | 5.6 ± 0.4 | 2.4 ± 0.6 | 0.0125 | Up |
| mmu-miR-181a | 5.6 ± 0.5 | 2.4 ± 0.6 | 0.0125 | Up |
| mmu-miR-30d | 1.2 ± 0.1 | 2.0 ± 0.2 | 0.0145 | Down |
| mmu-miR-96 | 1.3 ± 0.3 | 0.2 ± 0.1 | 0.0146 | Up |
| mmu-miR-31 | 0.7 ± 0.2 | 1.6 ± 0.1 | 0.0163 | Down |
| mmu-miR-503 | 2.7 ± 0.5 | 0.6 ± 0.1 | 0.0165 | Up |
| rno-miR-196c | 49.5 ± 10.6 | 8.0 ± 1.3 | 0.0178 | Up |
| mmu-miR-128a | 1.8 ± 0.3 | 0.7 ± 0.1 | 0.0182 | Up |
| mmu-miR-26a | 0.6 ± 0.0 | 2.1 ± 0.4 | 0.0184 | Down |
| mmu-miR-340-5p | 1.9 ± 0.1 | 2.6 ± 0.2 | 0.0187 | Down |
| mmu-let-7f | 1.0 ± 0.2 | 2.4 ± 0.3 | 0.0192 | Down |
| mmu-miR-322 | 1.5 ± 0.1 | 0.9 ± 0.1 | 0.0196 | Up |
| mmu-let-7b | 0.7 ± 0.1 | 1.4 ± 0.2 | 0.0209 | Down |
| mmu-miR-15b | 1.9 ± 0.2 | 1.0 ± 0.1 | 0.0214 | Up |
| mmu-miR-192 | 0.3 ± 0.0 | 1.3 ± 0.3 | 0.0238 | Down |
| mmu-miR-125b-5p | 0.7 ± 0.1 | 1.4 ± 0.2 | 0.0246 | Down |
| mmu-miR-99b | 4.2 ± 0.6 | 1.6 ± 0.3 | 0.0247 | Up |