Table 1. Clinical and laboratory features discriminating chronic MCL from acute MCL.
| Disease-related Feature/Finding |
Chronic MCL | Acute MCL |
|---|---|---|
| MCs on BM smears ≥20% | + | + |
| Many MCs are mature MCs | + | − |
| Metachromatic blasts | − | + |
| MCs display KIT D816V | −/+ | +/− |
| MCs express CD25 | +/− | + |
| MCs express CD30 | +/− | +/− |
| MCs frequently express Ki-67 | − | +/− |
| C-Findings: | ||
| Marked anemia (Hb<10 g/dL) | − | +/− |
| Marked neutropenia (ANC<1,000/µL) | − | +/− |
| Marked thrombocytopenia (PLT<100,000) | − | +/− |
| Other C-Findings | − | +/− |
| Eosinophilia | +/− | +/− |
| Splenomegaly | +/− | + |
| Lymphadenopathy | −/+ | +/− |
MCL, mast cell leukemia; MCs, mast cells; BM, bone marrow; Hb, hemoglobin concentration; g/dL, gram per deciliter; ANC, absolute neutrophil count; PLT, platelet count.