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. Author manuscript; available in PMC: 2016 Jun 7.
Published in final edited form as: Future Med Chem. 2016 Mar 15;8(4):463–489. doi: 10.4155/fmc.16.5

Table 4.

Eg5 Inhibitors targeting the α4/α6 allosteric site and their biological activities

Compound Identifier Structure Eg5 Biochemical IC50 (nM)a References
GSK-1 28 graphic file with name emss-68393-i027.jpg 1.8b [106]
GSK-2 29 graphic file with name emss-68393-i028.jpg 8.8b [106]
GSK-3 30 graphic file with name emss-68393-i029.jpg 330b [106]
PVZB1194 31 graphic file with name emss-68393-i030.jpg 120 [107]
32 graphic file with name emss-68393-i031.jpg 31 [108]
33 graphic file with name emss-68393-i032.jpg 45 [109]
BI8 34 graphic file with name emss-68393-i033.jpg 590 [110]
35 graphic file with name emss-68393-i034.jpg 520 [110]
a

Biological activity values are IC50s determined in microtubule-stimulated biochemical assay unless otherwise stated;

b

Microtubule-stimulated ATPase activity expressed as Kiapp.