Table 2. MICs of 80 nm Pd@Ag NSs against 44 cryptococcal isolates with different molecular types or from different sources compared to fluconazole and amphotericin B.
| MIC(μg/mL) | ||||
|---|---|---|---|---|
| Strain | Pd@Ag (80nm) | FLZ | AmB | Annotation |
| C. neoformans | ||||
| WM148 | 0.5 | 32 | 0.5 | Cn VNI |
| WM626 | 2 | 2 | 0.5 | Cn VNII |
| WM628 | 0.25 | 8 | 0.5 | Cn VNIII |
| WM629 | 0.25 | 4 | 0.5 | Cn VNIV |
| SCZ50097 | 1 | 16 | 1 | Clinical (Cn VNI) |
| SCZ 50098 | 2 | >64 | 4 | Clinical (Cn VNI) |
| SCZ 50099 | 1 | 16 | 1 | Clinical (Cn VNI) |
| SCZ 50100 | 2 | 8 | 0.5 | Clinical (Cn VNI) |
| SCZ 50101 | 1 | 16 | 0.5 | Clinical (Cn VNI) |
| SCZ 50102 | 1 | 16 | 0.5 | Clinical (Cn VNI) |
| SCZ 50103 | 1 | 8 | 0.5 | Clinical (Cn VNI) |
| SCZ 50104 | 1 | 8 | 0.5 | Clinical (Cn VNI) |
| SCZ 50105 | 2 | 16 | 0.5 | Clinical (Cn VNI) |
| SCZ 50106 | 2 | 8 | 1 | Clinical (Cn VNI) |
| SCZ 50107 | 1 | 16 | 0.5 | Clinical (Cn VNI) |
| SCZ 50108 | 0.5 | 16 | 1 | Clinical (Cn VNI) |
| SCZ 50109 | 2 | 16 | 0.5 | Clinical (Cn VNI) |
| SCZ 50110 | 1 | 4 | 0.5 | Clinical (Cn VNI) |
| SCZ 50111 | 1 | 8 | 1 | Clinical (Cn VNI) |
| SCZ 50112 | 0.5 | >64 | 0.5 | Clinical (Cn VNI) |
| SCZ 50124 | 1 | 8 | 1 | Environmental (Cn VNI) |
| SCZ 50125 | 2 | 16 | 0.5 | Environmental (Cn VNI) |
| SCZ 50126 | 2 | 32 | 0.5 | Environmental (Cn VNI) |
| SCZ 50127 | 1 | 16 | 1 | Environmental (Cn VNI) |
| Range | 0.25–2 | 2->64 | 0.5–4 | |
| C. gattii | ||||
| WM179 | 2 | 8 | 0.5 | Cg VGI |
| WM178 | 0.5 | 16 | 1 | Cg VGII |
| WM161 | 0.25 | 8 | 0.5 | Cg VGIII |
| WM779 | 1 | 32 | 0.5 | Cg VGIV |
| EJB76 | 1 | 64 | 1 | Animal (Cg VGIIb) |
| EJB52 | 1 | 16 | 0.5 | Animal (Cg VGIIc) |
| CBS10090 | 1 | 64 | 1 | Clinical (Cg VGII) |
| EJB21 | 1 | 32 | 0.5 | Clinical (Cg VGIIa) |
| ICB107 | 1 | 16 | 0.25 | Clinical (Cg VGIIa) |
| NIH444 | 1 | 16 | 1 | Clinical (Cg VGIIa) |
| A6MR38 | 1 | 32 | 0.5 | Clinical (Cg VGIIc) |
| EJB11 | 1 | 64 | 1 | Clinical (Cg VGIIIa) |
| NIH112 | 1 | 16 | 0.5 | Clinical (Cg VGIIIb) |
| ICB108 | 1 | 16 | 0.25 | Clinical (Cg VGIIIb) |
| MMRL2872 | 1 | 32 | 0.5 | Clinical (Cg VGIV) |
| MMRL3019 | 1 | 16 | 0.5 | Clinical (Cg VGIV) |
| WM276 | 0.5 | 32 | 0.5 | Environmental (Cg VGI) |
| E555 | 0.5 | 16 | 0.25 | Environmental (Cg VGI) |
| CBS7750 | 0.5 | 16 | 0.5 | Environmental (Cg VGIIa) |
| Ram2 | 1 | 32 | 0.5 | Environmental (Cg VGIIb) |
| Range | 0.25–2 | 8–64 | 0.25–1 | |
Cn, C. neoformans; Cg, C. gattii. VNI-VNIV represent the molecular types of C. neoformans, and VGI-VGIV represent the molecular types of C. gattii.