Table 3. 80 nm Pd@Ag NSs and amphotericin B exhibit a synergistic fungicidal effect.
Species | Strains | MIC(μg/mL) | FICI | MFC(μg/mL) | FFCI | ||||
---|---|---|---|---|---|---|---|---|---|
Pd@Ag | AmB | Pd@Ag/AmB | Pd@Ag | AmB | Pd@Ag/AmB | ||||
C. neoformans | H99 | 0.5 | 0.125 | 0.06/0.004 | 0.152 | 32 | 2 | 4/0.004 | 0.127 |
C. gattii | R265 | 0.5 | 0.5 | 0.06/0.004 | 0.128 | 32 | 1 | 8/0.008 | 0.258 |
C. neoformans | WM629 | 0.25 | 0.5 | 0.06/0.004 | 0.248 | 32 | 2 | 8/0.004 | 0.252 |
C. neoformans | WM628 | 0.25 | 0.5 | 0.06/0.004 | 0.248 | 64 | 1 | 16/0.06 | 0.310 |
C. neoformans | WM148 | 0.5 | 0.5 | 0.06/0.004 | 0.128 | 64 | 1 | 8/0.06 | 0.185 |
C. neoformans | WM626 | 2 | 0.5 | 0.06/0.004 | 0.038 | 128 | 2 | 16/0.125 | 0.188 |
C.gattii | WM161 | 0.25 | 0.5 | 0.06/0.004 | 0.248 | 64 | 2 | 4/0.125 | 0.125 |
C.gattii | WM178 | 0.5 | 1 | 0.06/0.004 | 0.124 | 32 | 1 | 4/0.015 | 0.140 |
C.gattii | WM179 | 2 | 0.5 | 0.06/0.004 | 0.038 | 128 | 2 | 8/0.06 | 0.093 |
C.gattii | WM779 | 1 | 0.5 | 0.06/0.004 | 0.068 | 64 | 1 | 16/0.125 | 0.375 |