Fig 6. Quantitation of the effects of wounding and Ibuprofen on melanoma cell invasion in TE skin constructs.

(A) with HBL cells, (B) with A375SM cells and (C) with C8161 cells. To the constructs were added W=Wound, Fn=Fibrin clots, TNF=300U/ml TNF-α, NaIbu=Ibuprofen sodium salt as shown. Values (bars) are expressed as Mean+SEM of invasion score. * indicates p<0.05; ** indicates p<0.01.