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. 2016 Jun 7;11(6):e0156931. doi: 10.1371/journal.pone.0156931

Table 2. Effect of fibrin clot, TNF-α and skin cells on wound healing.

Fibroblasts Wound Fibrin TNF-α Keratinocytes Result
- - - - - Normal DED
- - + - - Normal DED
- + - - - Open wide wound (Fig 3A)
- + + - - Narrowed wound (Fig 3B)
+ - - - - Normal Dermis + F
+ - + - - Normal Dermis + F
+ + - - - Healed (Fig 3C)
+ + + - - Narrowed wound (Fig 3D)
+ + - - + Open wide wound (Fig 3E, 3F and 3G)
+ + + + + Epidermis healed, healed wound (Fig 3H)
+ + + + + Epidermis healed, narrowed wound (Fig 3I)

Fibrin = Fibrin Clots, TNF = 300U/ml TNF-α, F = Fibroblasts.