Fig 4. Photomicrographs showing the histological study of the absolute ethanol-induced gastric mucosal damage in rats.

(4a) Rats pre-treated with 5 ml/kg of 10% Tween 20 (ulcer control). There is severe disruption to the surface epithelium and necrotic lesions penetrate deeply into mucosa (white arrow) and extensive edema of submucosa layer and leucocyte infiltration are present (black arrow). (4b) Rats pre-treated with omeprazole (20 mg/kg). Mild disruption of the surface epithelium mucosa is present (white arrow) but deep mucosal damage is absent. Reduction of submucosal edema and leucocytes infiltration (black arrow). (4c) Rat pre-treated with compound 1(50 mg/kg), mild disruption of surface epithelium are present but deep mucosal damage is absent. Reduction of submucosal edema and leucocytes infiltration (black arrow). (4d) Rat pre-treated with compound 1 (100 mg/kg), mild disruption of surface epithelium is present but deep mucosal damage is absent. Reduction of submucosal edema and leucocytes infiltration (black arrow). (4e) Rats in the normal control group showed intact gastric mucosa.