Table 3. Effects of compound 1 on liver function test in rats.
| Dose | Total protein (g/L) | Albumin (g/L) | Globulin (g/L) | TB (μmol/L) | CB (μmol/L) | AP (IU/L) | ALT(IU/L) | AST (IU/L) | GGT (IU/L) |
|---|---|---|---|---|---|---|---|---|---|
| Vehicle | 64.23 ± 1.28 | 11.257 ± 0.28 | 53.57 ± 1.79 | 2.00 ± 0.00 | 1.00 ± 0.00 | 111.72 ± 6.22 | 43.41 ± 1.97 | 169.10 ± 6.82 | 3.78 ± 0.39 |
| (500mg/kg) | 62.15 ± 1.19 | 10.78 ± 0.31 | 52.43 ± 1.63 | 2.00 ± 0.006 | 1.00 ± 0.00 | 98.81 ± 5.51 | 40.27 ± 2.16 | 174.25 ± 8.65 | 3.53 ± 0.51 |
Values expressed as mean ± S.E.M. There are no significant differences between groups. Significant value at p<0.05.
TB: Total bilirubin; CB: Conjugated bilirubin; AP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase;GGT: G-Glutamyl Transferase.