Table 4. Effect of compound 1 on mucus production, acidity, ulcer area and inhibition percentage in rats.
| Animal group | Pre-treatment (5ml/kg) | pH of Gastrictissue | Mucus weight (g) | Ulcer Area (mm) (mean ± S.E.M) | % Inhibition |
|---|---|---|---|---|---|
| 1 | 10% Twee20 (ulcer control) | 2.95±0.40 | 0.512±0.015 | 850.00±14.43 | - |
| 2 | Omeprazole (20mg/kg) | 5.60±0.50 a | 0.46±0.025 a | 178±9.6 a | 79 |
| 3 | Compound 1 (50 mg/kg) | 5.02 ± 0.48 a | 0.50 ± 0.098 | 63.36 ± 34.80 a | 92.6 |
| 4 | Compound 1 (100 mg/kg) | 3.9±0.9 a | 0.44 ± 0.06 a | 18.72 ± 5.42 a | 97.8 |
| 5 | Normal | 7.05±0.6 a | 0.586±0.031 | 0 | - |
Values are assumed as mean ± S.E.M. The statistical analysis was assessed with one-way ANOVA (post hoc analysis) with P < 0.05.
*Significant differences when compared to group 1.