Table 1. Displacement Binding Profiles.
| pKi | ||||
|---|---|---|---|---|
| CHOhMu | CHOhNOP | CHOhDelta | CHOhKappa | |
| Reference ligand | - | - | 10.02 (±0.26) | 10.16 (±0.02) |
| dermorphin | 8.69 (±0.10) | <5 | 7.17 (±0.11) | <5 |
| N/OFQ | <5 | 10.69 (±0.10) | <5 | <5 |
| DeNo | 9.55 (±0.10)* | 10.22 (±0.09) | 8.12 (±0.11)* | 7.34(±0.13)* |
pKi values for both the reference ligands, dermorphin, N/OFQ and DeNo. Data are displayed as mean (±SEM) of n = 5 experiments. Statistical significance (*) demonstrates p<0.05, using one-way ANOVA with Dunnett’s correction, when compared to the reference ligands dermophin (Mu), N/OFQ (NOP), Naltrindole (Delta) and Dynorphin-A (Kappa).