Table 2. Calcium Mobilisation.
NOP | Mu | |||
---|---|---|---|---|
pEC50 (CL95%) | Emax ± SEM | pEC50 (CL95%) | Emax ± SEM | |
N/OFQ | 9.85(9.37–10.33) | 279 ± 44% | Inactive | |
dermorphin | crc incomplete | 8.07(7.85–8.29) | 234 ± 14% | |
DeNo | 9.69(9.35–10.03) | 244 ± 6% | 7.17(6.91–7.43) | 209 ± 15% |
Effects of N/OFQ, dermorphin and DeNo in calcium mobilisation experiments performed in CHO cells stably expressing the human NOP or Mu receptor and the Gαqi5 protein. Data are expressed as the mean (±SEM) of at least 3 experiments performed in duplicate. For potency values 95% confidence limits were indicated. Data have been analysed with one way ANOVA followed by the Dunnett’s test for multiple comparisons; p values less than 0.05 were considered to be significant.