Table 1.
Clinical characteristics of the 3 molecular subtypes of adult medulloblastoma
| Characteristic | SHH (n = 124) | WNT (n = 20) | Group 4 (n = 57) | P (χ2) |
|---|---|---|---|---|
| No. of Patients (%) | No. of Patients (%) | No. of Patients (%) | ||
| Sex | ||||
| Male | 88 (70.97) | 7 (35.00) | 38 (66.67) | .007 |
| Female | 36 (29.03) | 13 (65.00) | 19 (33.33) | |
| Tumor location | ||||
| Midline | 55 (44.35) | 14 (70.00) | 43 (75.44) | 1.9–e4 |
| Hemisphere | 69 (55.65) | 6 (30.00) | 14 (24.56) | |
| Tumor size | ||||
| ≤4 cm | 59 (47.58) | 13 (65.00) | 29 (50.88) | .349 |
| >4 cm | 65 (52.42) | 7 (35.00) | 28 (49.12) | |
| V4 floor involvement | ||||
| Yes | 53 (42.74) | 9 (45.00) | 40 (70.18) | .002 |
| No | 71 (57.26) | 11 (55.00) | 17 (29.82) | |
| Metastasis classification | ||||
| M0 | 104 (83.87) | 18 (90.00) | 44 (77.19) | .282 |
| M+ | 20 (16.13) | 2 (10.00) | 13 (22.81) | |
| Surgical resection | ||||
| GTR | 77 (62.10) | 11 (55.00) | 26 (45.61) | .114 |
| STR | 47 (37.90) | 9 (45.00) | 31 (54.39) | |
| Histology | ||||
| CMB | 58 (46.77) | 19 (95.00) | 37 (64.91) | 1.5–e6 |
| DNMB | 43 (34.68) | 1 (5.00) | 3 (5.26) | |
| LC/A MB | 23 (18.55) | 0 (0) | 17 (29.83) | |
| Risk | ||||
| Average | 70 (56.45) | 17 (85.00) | 26 (45.61) | .020 |
| High | 54 (43.55) | 3 (15.00) | 31 (54.39) | |
Abbreviations: GTR, gross total resection; STR, subtotal resection; V4, fourth ventricle.