Table 2.
Univariate analysis for clinical, histopathological, and molecular variables with regard to impact on survival for adult MBs
| Variables | OS |
PFS |
||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | P | Hazard Ratio | 95% CI | P | |
| Sex, male vs female | 1.450 | 0.805–2.611 | .216 | 1.145 | 0.720–1.822 | .567 |
| Tumor location, midline vs hemisphere | 0.562 | 0.325–0.973 | .039 | 0.633 | 0.404–0.990 | .045 |
| Tumor size (cm), >4 vs ≤4 | 1.067 | 0.636–1.790 | .806 | 1.088 | 0.707–1.673 | .703 |
| V4 floor involvement, yes vs no | 1.630 | 0.962–2.762 | .070 | 1.386 | 0.898–2.140 | .141 |
| Metastasis, M+ vs M0 | 3.669 | 2.123–6.342 | 3.2e-6 | 3.311 | 2.061–5.318 | 7.3e-7 |
| VP shunt, yes vs no | 0.633 | 0.299–1.337 | .230 | 0.677 | 0.367–1.248 | .211 |
| Resection, GTR vs STR | 0.647 | 0.385–1.085 | .099 | 0.670 | 0.435–1.031 | .068 |
| Radiotherapy, WBI vs CSI | 4.284 | 2.207–8.316 | 1.7e-6 | 3.712 | 2.005–6.874 | 3.0e-5 |
| Chemotherapy, yes vs no | 0.845 | 0.488–1.465 | .548 | 1.069 | 0.660–1.731 | .787 |
| Histology | ||||||
| DNMB vs classic | 0.607 | 0.264–1.394 | .239 | 0.480 | 0.234–0.986 | .046 |
| Anaplastic vs classic | 1.910 | 1.428–2.553 | 1.3e-5 | 1.828 | 1.429–2.339 | 1.5e-6 |
| Large cell vs classic | 1.190 | 0.734–1.930 | .480 | 1.406 | 1.029–1.920 | .032 |
| Molecular subgroup | ||||||
| WNT vs SHH | 0.377 | 0.089–1.594 | .185 | 0.376 | 0.116–1.217 | .103 |
| Group 4 vs SHH | 1.887 | 1.443–2.467 | 3.5e-6 | 1.845 | 1.476–2.307 | 7.8e-8 |
| WNT vs group 4 | 0.056 | 0.008–0.416 | .005 | 0.091 | 0.027–0.308 | 1.2e-4 |
Abbreviations: CSI, craniospinal irradiation; GTR, gross total resection; STR, subtotal resection; V4, fourth ventricle; VP, ventriculoperitoneal; WBI, whole-brain irradiation.