Table 3.
Multivariate Cox proportional hazards model for selected clinical, histopathological, and molecular variables with regard to impact on survival for adult medulloblastomas
| Variables | OS |
PFS |
||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | P | Hazard Ratio | 95% CI | P | |
| Metastasis, M+ vs M0 | 0.370 | 0.208–0.657 | 0.001 | 0.333 | 0.202–0.551 | 1.8e-5 |
| Radiotherapy, WBI vs CSI | 5.277 | 2.574–10.815 | 5.6e-6 | 5.590 | 2.873–10.877 | 4.0e-7 |
| Histology | ||||||
| DNMB vs classic | 1.024 | 0.415–2.528 | 0.958 | 0.713 | 0.330–1.539 | 0.389 |
| Anaplastic vs classic | 2.645 | 1.422–4.920 | 0.002 | 2.537 | 1.506–4.274 | 4.7e-4 |
| Large cell vs classic | 1.335 | 0.309–5.772 | 0.699 | 1.807 | 0.698–4.678 | 0.223 |
| Molecular subgroup | ||||||
| WNT vs SHH | 0.367 | 0.085–1.592 | 0.181 | 0.303 | 0.091–1.008 | 0.051 |
| Group 4 vs SHH | 2.881 | 1.617–5.134 | 3.3e-4 | 2.720 | 1.686–4.389 | 4.1e-5 |
Abbreviations: CSI, craniospinal irradiation; WBI, whole-brain irradiation.