Figure 4. HIV-1 Env-specific IgG titers in rabbits immunized with DP6-001 ISCOMATRIX™ vaccine. New Zealand white rabbits (n = 5/experimental group) were primed with DP6-001 DNA and boosted with DP6-001 protein formulated with Al(OH)3 (D+P-Al[OH]3) or ISCOMATRIX™ adjuvant (D+P-IMX). As a control, rabbits were immunized with empty vector DNA prime followed by boost with the DP6-001 protein formulated with ISCOMATRIX™ adjuvant (V+P-IMX). Env-specific IgG responses were determined at different time points in pooled samples (A) and endpoint titers were determined on week 20 in individual samples (B) by ELISA. (IMX = ISCOMATRIX™ adjuvant)