Table 2. Liposomal dose formulations composition and characterization.
| Compositiona, mg | Dose characteristics | |||||||
|---|---|---|---|---|---|---|---|---|
| Liposomal Formulation | SUV (lipid) |
DNA (AV-1959D) |
Protein (AV-1982R) |
Sucrose | Size nm, PDI |
Zeta mV |
DNA dose µg |
Protein dose µg |
| A (DNA and Protein) | 6.250 | 0.025 | 0.050 | 18.750 | 149 ± 2, 0.46 ± 0.05 |
18 ± 4 | 9.7 ± 1.0 | 18.6 ± 0.8 |
| B (DNA) | 6.250 | 0.025 | Nil | 18.750 | 134 ± 9, 0.35 ± 0.09 |
18 ± 5 | 10.0 ± 0.3 | NA |
| C (Protein) | 6.250 | Nil | 0.050 | 18.750 | 112 ± 3, 0.25 ± 0.01 |
17 ± 8 | NA | 22.3 ± 2.5 |
a
2.5 dose vial fill, ave ± stdev with n > 3.