Table 2. Survival data and mean values of mice weight challenged with different doses of native AT.
| Dose of native toxins | Immunization time interval | i.p. injection | s.c. injection | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 15 μg | 25 μg | 15 μg | 25 μg | ||||||
| Alive/totala | Mean of weight (g)b | Alive/totala | Mean of weight (g)b | Alive/totala | Mean of weight (g)b | Alive/totala | Mean of weight (g)b | ||
| 2 × LD50 | І | 5/5 | 22.23 ± 0.46 | 5/5 | 22.77 ± 0.63 | 5/5 | 23.21 ± 0.63 | 5/5 | 22.66 ± 0.81 |
| Π | 5/5 | 23.23 ± 0.44 | 5/5 | 23.34 ± 0.47 | 5/5 | 23.21 ± 0.72 | 5/5 | 22.24 ± 0.58 | |
| 4 × LD50 | І | 3/5 | 21.99 ± 0.67 | 4/5 | 22.16 ± 0.37 | 2/5 | 20.42 ± 0.70 | 2/5 | 20.43 ± 0.55 |
| Π | 3/5 | 22.01 ± 082 | 5/5 | 21.55 ± 0.72 | 2/5 | 21.09 ± 0.65 | 2/5 | 20.61 ± 0.81 | |
a Eighty Balb/C mice were randomly divided into 16 subgroups and challenged with 2 × or 4 × LD50 of native AT. bComparisons of weight loss among 16 subgroups indicate no significant difference. The survival of mice was recorded daily for 10 d.