Figure 3. Serum Bet v 1-specific IgE levels and IgE/IgG2a ratios. (A) Significantly higher rBet v 1-specific IgE level are found in sensitized/not treated or treated mice compared with naïve (P < 0.001). Among treated, ST[rBet v 1] group is associated with significantly lower levels of allergen-specific IgE (P < 0.001 vs ST and ST+rBet v 1). (B) Only the group treated with ST[rBet v 1] showed a significant reduction of the IgE/IgG2a ratio, compared with the sensitized/not treated group (P < 0.001). Data are the mean ± standard deviation. ANOVA: § = P < 0.001 naïve vs all other groups; **P < 0.01; ***P < 0.001. naïve: not sensitized, not treated mice; sensitized: sensitized, not treated mice; ST: wild type Streptococcus thermophilus-treated mice; ST[rBet v 1]: mice treated with recombinant Streptococcus thermophilus expressing rBet v 1; ST+rBet v 1: mice treated with recombinant wild type Streptococcus thermophilus and rBet v 1.