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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: J Am Chem Soc. 2015 Jul 2;137(27):8712–8715. doi: 10.1021/jacs.5b05477

Scheme 3. Tandem Directed Diboration/Directed Cross-Coupling.a.

Scheme 3

aCross-coupling: aryl electrophiles employed 0.5% Pd2(dba)3, 1% RuPhos and 1.5 equiv ArX; alkenyl electrophiles employed 2.5% Pd(OAc)2, 3% RuPhos and 1.5 equiv alkenyl halide. Yield represents isolated yield of purified material and is an average of two experiments. bCross-coupling employed 10% Pd(OAc)2 and 12% RuPhos.