Skip to main content
. Author manuscript; available in PMC: 2016 Jun 7.
Published in final edited form as: Sci Signal. 2016 May 24;9(429):ra53. doi: 10.1126/scisignal.aad8170

Figure 7. Like E2, PaPE-1 elicits repair of the vascular endothelium after injury, an effect that is prevented by the antiestrogen ICI.

Figure 7

(A) Carotid artery reendothelialization after an injury that denudes the endothelial layer in ovariectomized mice treated with PaPE-1 or E2 in the absence or presence of the antiestrogen ICI 182,780 (ICI) (N=6–9 mice/group). *, p<0.05 compared to basal control. Scale bar, 400 μm. (B) E2, but not PaPE-1, increases uterine weight, an effect that is blocked by ICI. N=7 mice/treatment. (C) eNOS stimulation by E2 and PaPE-1 in the presence and absence of the antiestrogen ICI 182,780 in BAECs. N= 4 biological replicates. *, p<0.05 compared to control.