Striatal muscarinic receptors mediated SChI-induced beta and gamma oscillations in the striatum and M1. (A and B) Optogenetic stimulation induced changes in the power spectrum before (A) and after (B) scopolamine infusion (n = 8 mice), in the striatum (i), superficial (ii), middle (iii), and deep layers of M1 (iv). The power spectrum during laser stimulation (blue) and after laser stimulation (green) was normalized to the baseline (black). (C) Bar plot comparison of oscillation power changes in beta (15–30 Hz), low gamma (30–60 Hz), and high gamma (60–100 Hz) frequencies, before (gray) and after (white) scopolamine infusion. Error bars are the bootstrapped 95% confidence intervals (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; nonparametric bootstrap test).