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Electron density of the 4-N-Ac-Sia-substrate analog bound in the RCoV-NJ HE0 esterase catalytic site (A) and lectin site (B). The model used for difference density calculation did not contain the substrate analog and had been obtained by refining the crystal structure of free RCoV-NJ HE0 against the diffraction data of the substrate analog complex without manual model building (Rfree = 20%). The contour level is 3.0 σ.
