Table 4.

Effect of rsp mutation on S. aureus

Pathway/effect/phenomenon	rsp wild-type	rsp mutants
Intracellularity	Rapid host cell lysis after endocytosis	Prolonged intracellular residence after endocytosis
Cytotoxicity	Cytotoxicity (epithelial cells, neutrophils)	Reduced cytotoxicity
Hemolysis	Normal α-toxin hemolysis	Strongly reduced α-toxin hemolysis
SSR42 expression	SSR42 expression (6% of mRNA)	Absent SSR42 expression
Virulence	Lethality (murine sepsis and pneumonia)	Reduced lethality
Peroxide response	Virulence response to peroxide	Reduced peroxide response
Source	Identified in nasal carriage isolates	Identified in bloodstream isolates