Umbilical vein velocity (A), umbilical artery resistance index (B), and fetal cardiac E/A wave ratio (C) in Hsd11b2+/+, Hsd11b2+/−, and Hsd11b2−/− fetuses at E14.5 and E17.5. Values were normalized for fetal weight and are the mean ± SEM (n = 8 per group). Columns without common notation differ significantly (P < 0.05, two-way ANOVA, Tukey’s post hoc test).