Fig. 3.

Comparison of the kinetics of HDX for five regions of DBP in the presence of various mAbs (holo state, depicted in red) and in the absence of the mAb (apo state, depicted in blue). Each region (column) is represented by a peptic peptide and its charge state, as measured by mass spectrometry. Each row represents a state bound with a mAb; the antibody is listed on the right. Those regions showing reduced rates or extents of exchange for the holo state (red) are considered to contain the epitopes. Those regions showing no difference are examples of region that do not contain the epitopes, and can be viewed as controls.