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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Neuron. 2016 May 12;90(5):969–983. doi: 10.1016/j.neuron.2016.04.015

Figure 6. In Vivo Over-Expression of Susceptible-Specific Hub Genes Induces a Susceptible Behavioral Profile.

Figure 6

(A) Schematic of in vivo behavioral validation of susceptible-specific hub genes. Representative images of HSV-GFP infection in VHIP (B) and PFC (F). Scale bar=100μm. Mice injected with (C) HSV-Dkkl1-GFP, (D) HSV-Neurod2-GFP or (E) HSV-Sdk1-GFP in VHIP spent significantly less time in proximity to the wire mesh enclosure (Interaction Zone) compared to mice injected with HSV-GFP indicating increased susceptibility. Mice injected with the same viral constructs in PFC spent more time in the interaction zone (I; HSV-Sdk1-GFP) or an equivalent amount of time (G; HSV-Dkkl1-GFP, H; HSV-Neurod2-GFP) compared to HSV-GFP injected mice indicating increased resilience or lack of susceptibility. * p<0.05, **p<0.01. Bar graphs show mean ±SEM. See also Figure S6.