Table 3. Questions on oral immunotherapy.

Eligibility	What is the best age to do oral immunotherapy? Does treatment efficacy vary in different subgroup? Does treatment safety vary in different subgroup?
Dosing	What is the optimal starting dose? What is the optimal maintenance dose to balance patient effort and tolerance? What is the optimal maintenance duration to achieve tolerance? How to proceed when allergic to multiple foods? What is the maximum number of foods that can be desensitized simultaneously?
Safety	How to manage dosing reactions? What is the true risk of Eosinophilic Esophagitis? Use of medication to increase desensitization speed?
Tolerance	What is the rate of tolerance? When and how should tolerance be tested? What is the goal: Desensitization vs Tolerance?
Product	Could the food be modified to be more tolerogenic? Would other routes of administration increase safety or efficacy?