Table 4. Studies measuring the induction of sustained tolerance.
Trial | Food | N | Maintenance dose | Timing of OIT | Length of avoidance | Sustained tolerance |
---|---|---|---|---|---|---|
Staden 20078 | Milk or Egg | 25 | 3300 mg milk or 1600mg egg + deliberate intake | 21 mo total with 7–15 mo of maintenance (median 9 mo) | 2 mo | 9/25 (36%) of 4770mg milk or 6200mg egg; 7/20 (35%) of control tolerant |
Blumchen 201029 | Peanut | 23 | Minimum of 500mg | 9 mo total with 2 mo of maintenance | 2 wk | 3/23 (13%) tolerated 4g; 11/23 (48%) tolerated 500mg |
Keet 201215 | Milk | 30 | SLIT to 7mg SLIT + OIT to 1000mg or SLIT + OIT to 2000mg |
68–90 wk of total therapy with 60 wks maintenance | 1 and 6 wk | 1/10 in SLIT, 4/10 in 1000mg, 8/10 in 2000mg passed 8 g challenge at 1 wk; 1 /10 in SLIT, 3/10 in 1000mg, 5/10 in 2000mg passed 8 g challenge at 6 wk at 6 wk |
Burks 201223 | Egg | 40 | 1600 mg egg protein | 22 mo of total therapy | 4–6 wk | 11/40 (28%) to 8g protein |
Vickery 201334 | Peanut | 39 | 4000mg peanut protein | 5 y of total therapy | 4 wk | 12/39 (31%) to 5g protein |
Syed 201435 |
Peanut | 23 | 4000mg peanut protein | 24 mo of total therapy | 3 mo (27 mo) and an additional 3 mo (30 mo) | 7/23 (30%) at 27 mo to 4g; 3/23 (13%) at 30 mo to 4g |