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. 2014 Jun 5;10(8):2295–2302. doi: 10.4161/hv.29233

Table 4. Studies measuring the induction of sustained tolerance.

Trial Food N Maintenance dose Timing of OIT Length of avoidance Sustained tolerance
Staden 20078 Milk or Egg 25 3300 mg milk or 1600mg egg + deliberate intake 21 mo total with 7–15 mo of maintenance (median 9 mo) 2 mo 9/25 (36%) of 4770mg milk or 6200mg egg;
7/20 (35%) of control tolerant
Blumchen 201029 Peanut 23 Minimum of 500mg 9 mo total with 2 mo of maintenance 2 wk 3/23 (13%) tolerated 4g; 11/23 (48%) tolerated 500mg
Keet 201215 Milk 30 SLIT to 7mg
SLIT + OIT to 1000mg or
SLIT + OIT to 2000mg
68–90 wk of total therapy with 60 wks maintenance 1 and 6 wk 1/10 in SLIT, 4/10 in 1000mg,
8/10 in 2000mg passed 8 g challenge at 1 wk;
1 /10 in SLIT, 3/10 in 1000mg,
5/10 in 2000mg passed 8 g challenge at 6 wk at 6 wk
Burks 201223 Egg 40 1600 mg egg protein 22 mo of total therapy 4–6 wk 11/40 (28%) to 8g protein
Vickery 201334 Peanut 39 4000mg peanut protein 5 y of total therapy 4 wk 12/39 (31%) to 5g protein
Syed
201435
Peanut 23 4000mg peanut protein 24 mo of total therapy 3 mo (27 mo) and an additional 3 mo (30 mo) 7/23 (30%) at 27 mo to 4g; 3/23 (13%) at 30 mo to 4g