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. 2014 Jun 5;10(8):2295–2302. doi: 10.4161/hv.29233

Table 5. Studies measuring the impact of OIT on quality of life.

Trial Number of Subjects (ages) Intervention QoL Change
Carraro (2012)46 30 (3–12 y) Milk OIT Improvement in emotional impact, food related anxiety, and social and dietary limitations
Factor (2012)45 90 (5–18 y) Peanut OIT Improvement in all parameters of the survey: allergen avoidance, dietary restriction, risk of accidental exposure, emotional impact, food-related anxiety, and social and dietary limitations.
Parent assessment of their children 5 to 12 y old: significant improvement on all 30 questions (P < 0.02).
Children (8 –12 y old) assessed themselves: quality of life improved on 22 of 24 questions (P < 0.05).
Teens (13–18 y old) assessed themselves: quality of life improved on 12 of 18 questions (P < 0.05).
Anagostou (2014) 99 (7–16 y) Peanut OIT Improvement in quality of life scores assessed for 7–12 y olds by parents (median change –1·61; P < 0·001)
Otani (2014, under review) 40 (4–16 y) Multiple Allergen OIT Significant improvement in caregiver health-related quality of life (HRQL score out of 6) going from an average of 3.9 to 1.7 in 18 mo (P < 0.0001). All parameters in the questionnaire showed improvement. No change from baseline in control group on avoidance.