Table 1A. The protection conferred by the maternal antibodies against the lethal EV71 challenge in suckling mice. The female mice were immunized with the purified P1 protein; heat- inactivated EV71 at weeks 2,4,6 and allowed to conceive after the 3rd injections. The neonatal mice were born and then challenged i.p. with 10-50000 times LD50 dosage of A(BrCr ) or C(C4) subtype EV71 when one day old. The protection conferred by the maternal antibodies against the EV71 A(BrCr) subtype lethal EV71 challenge.
virus dosage |
P1group protection | Inactiveted EV71 group |
---|---|---|
5000LD50 | 100%(10/10) | 100%(11/11) |
10000LD50 | 90%(9/10) | 80%(8/10) |
25000LD50 | 50%(6/12) | 50%(5/10) |
50000LD50 | 10%(1/10) | 9%(1/11) |