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. 2014 Jul 22;10(8):2220–2226. doi: 10.4161/hv.29123

Table 1A. The protection conferred by the maternal antibodies against the lethal EV71 challenge in suckling mice. The female mice were immunized with the purified P1 protein; heat- inactivated EV71 at weeks 2,4,6 and allowed to conceive after the 3rd injections. The neonatal mice were born and then challenged i.p. with 10-50000 times LD50 dosage of A(BrCr ) or C(C4) subtype EV71 when one day old. The protection conferred by the maternal antibodies against the EV71 A(BrCr) subtype lethal EV71 challenge.


virus dosage
P1group protection Inactiveted EV71 group
5000LD50 100%(10/10) 100%(11/11)
10000LD50 90%(9/10) 80%(8/10)
25000LD50 50%(6/12) 50%(5/10)
50000LD50 10%(1/10) 9%(1/11)