TABLE 1.

ASPECT-R domains and definitions cf domain terminology^*

DOMAIN	DEFINITION OF DOMAIN TERMINOLOGY
Participant eligibility criteria	Considerations include the intended treatment population of interest that has been identified by the study’s authors (e.g., in the study title, objectives, discussion, conclusions)
Intervention flexibility	Considerations include posology, dose, dosing interval, windows allowed for dosing; permitted concomitant treatments. The domain is rated separately for experimental and comparisons treatment interventions
Medical practice setting/practitioner expertise	Considerations include experience, skills and resources of the practitioner and the treatment team; the healthcare delivery system; standards of care at the site, and local cultural practices that may influence medical delivery or outcomes. The domain is rated separately for experimental and comparisons treatment interventions.
Follow-up intensity and duration	Considerations include frequency and length of visits and the number and the scope of the assessments.
Outcome(s)	Considerations include evaluation of measure(s) by which the interventions’ effects are assessed and how well they reflect outcomes that are used and considered important to real world practice.
Participant adherence	Considerations include the degree to which the subjects are encouraged and tracked for adherence to study-related procedures.

^*Original domains, descriptors, and concept from Thorpe et al 2009 (see reference ¹)