Fig. 6.
Treatment with CUDC-101 reduces growth of 22Rv1 xenografts in SCID mice. Right panel change in weight of treated and control mice at baseline and after receiving CUDC-101 or DMSO for 14 days. Left panel 2 × 105 22Rv1 cells mixed with Matrigel were injected in the R flank of SCID mice. A sc tumor became palpable within 2 weeks. SCID mice were treated with CUDC-101 (50 μg/kg/day) or DMSO for 14 days. Tumors were measured with a caliper at the outset and after 14 days of treatment. Bars represent change in tumor size from baseline (mean ± SE) of 6 (CUDC-101) and 5 (DMSO) treated mice. *P < 0.05 when comparing xenografts treated with CUDC-101 and DMSO