Figure 1. Renal function in murine models of nephrotoxic and rhabdomyolysis-induced AKI.
Plasma creatinine levels are elevated as early as 4 hours after injection in mice with rhabdomyolysis-induced AKI (A, n=8) and are even further increased after 24 hours (B, n=7–9). In nephrotoxic AKI (n=8), elevated plasma creatinine levels are only seen after 24 hours (B). Similar changes are seen with plasma concentrations of cystatin C (B + C).