Fig. 6.

Inflammatory cytokine profile of S. pneumoniae infected mice. Lavages were isolated from the pleural cavities of saline and intrapleurally infected S. pneumoniae infected mice 7 and 14 days post infection. a Proinflammatory mediator expression was then assayed in the collected lavages by Bioplex assay. Pleural lavages showed significant changes in KC, IL-17A, MCP-1, MIP-1β, and IL-13 at 7 days by Bioplex analyses (P < 0.01). n = 6–8 mice/group. PGE₂ was extracted from the PLs of saline and S. pneumoniae-infected mice. PGE₂ levels were then determined by competitive ELISA. b PGE₂ expression was significantly increased in the lavages of S. pneumoniae infected WT mice at 7 days (*denotes a P < 0.05), n = 6–8 mice/group