Fig. 9.

Pleural inflammation and lavage neutrophilia is increased in PAI-1 deficiency after induction of S. pneumoniae mediated pleural injury. Pleural injury was induced in WT and PAI-1^−/− mice by intrapleural injection of S. pneumoniae for 3 days. PLs from saline and S. pneumoniae-infected WT and PAI-1^−/− mice demonstrated significant increases in KC, IL-4, IL-5, IL-6, IL-10, IL-12, MCP-1, G-CSF, and MIP-1β * denotes P < 0.05, n = 4–7 mice/group). S. pneumoniae infection significantly decreased IL-13 in WT mice (p < 0.05) when compared to controls. Saline-treated PAI-1^−/− mice demonstrated significantly less IL-13 than similarly treated WT mice (p < 0.05). n = 4–7 mice/group