Table 3.
Univariate characteristics in the evaluation of choledocholithiasis
| Criteria | Sensitivity% (95%CI) | Specificity% (95%CI) | PPV% (95%CI) | NPV% (95%CI) | Odds ratio (95%CI) | P-value |
| VS-PM | 81.2 (64-91) | 85.7 (42-99) | 96.8 (81-100) | 46.2 (20-74) | 25.7 (2.65-249) | 0.07 |
| S-PM | 59.5 (42-75) | 85.7 (42-99) | 95.7 (76-100) | 28.6 (12-52) | 8.8 (0.96-80.7) | 0.001 |
| VS-Adult | 59.5 (42-75) | 100 (56-100) | 100 (81-100) | 31.8 (15-55) | 18.8 (0.96-80.7) | 0.0001 |
| S-Adult | 48.6 (32-65) | 85.7 (42-99) | 94.7 (72-100) | 24 (10-45) | 5.68 (0.62-51.97) | 0.0001 |
| CBDS by US | 43.2 (28-60) | 100 (56-100) | 100 (76-100) | 25 (11-45) | 14.57 (0.50-41.9) | 0.0001 |
| CBD > 6 mm | 81.1 (64-91) | 14.3 (1-58) | 83.3 (67-93) | 12.5 (1-33) | 0.714 (0.074-6.92) | 1 |
| CBD > 8 mm | 91.7 (76-98) | 28.6 (5-70) | 86.8 (71-95) | 40 (7-83) | 4.4 (0.58-33.2) | 0.727 |
| TB > 4.0 | 21.6 (10-39) | 100 (56-100) | 100 (60-100) | 19.4 (8-37) | 11.66 (0.17-15.82) | 0.0001 |
| TB ≥ 1.8 | 56.8 (41-71) | 85.7 (49-97) | 95.5 (75-100) | 27.3 (12-50) | 7.88 (0.86-72.12) | 0.0001 |
| CB ≥ 0.5 | 67.6 (50-81) | 85.7 (42-99) | 96.2 (78-100) | 33.3 (14-59) | 12.5 (1-115) | 0.003 |
| ALT > 300 | 56.8 (40-72) | 14.3 (1-58) | 77.8 (57-91) | 5.9 (0-31) | 0.219 (0.024-2.00) | 0.052 |
| ALT > 350 | 40.5 (26-57) | 100 (56-100) | 100 (80-100) | 24.1 (11-42) | 14.1 (0.45-37.5) | 0.0001 |
| AST > 155 | 43.2 (28-60) | 85.7 (42-99) | 94 (69-100) | 22.2 (9-43) | 4.57 (0.499-41.9) | 0.0001 |
| γGT > 400 | 35.1 (21-53) | 100 (56-100) | 100 (72-100) | 22.6 (10-42) | 13.25 (0.352-30.0) | 0.0001 |
1
A zero denominator was substituted with a unit of one for odds ratio only. Includes sensitivity, specificity, positive predictive value, and odds ratio. P-values were calculated for each category for differences between patients with and without stones using McNemar’s test. PPV: Positive predictive value; NPV: Negative predictive value; VS-PM: Very Strong Pediatric “Modified”; S-PM: Strong Pediatric “Modified”; VS-Adult: Very Strong Adult; S-Adult: Strong Adult; CBDS: Common bile duct stone; CB: Conjugated bilirubin; TB: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; γGT: Gamma-glutamyl transferase; CBD: Common bile duct.